Lactobacillus rhamnosus CRL1505 vs. LGG: What Makes These Strains So Powerful?

Exploring CRL1505 and LGG: Dual Probiotic Power for Immunity and Gut Health

Lactobacillus rhamnosus CRL1505 and Lactobacillus rhamnosus GG (LGG) are two of the most clinically studied probiotic strains. They are both well-supported by scientific evidence for promoting digestive health, modulating the immune system, and maintaining upper respiratory tract wellness.


About Lactobacillus rhamnosus CRL1505

Originally isolated from the oral cavity of healthy children, CRL1505 is a patented probiotic strain with proven benefits, particularly in immune system regulation and upper respiratory support. Ideal for daily immune support, it’s especially suitable for individuals who need enhanced immune defense.
1. Supports Respiratory Immune Defenses
CRL1505 helps stimulate the secretion of mucosal immunoglobulin A (IgA), enhancing the protective barrier of the nasal and throat mucosa to help defend against common environmental challenges.
2. Maintains Gut Microbiota Balance
In addition to respiratory support, CRL1505 helps sustain a balanced intestinal microbiome, fostering a healthy digestive environment and supporting gut-related immune function—a comprehensive inside-out approach to wellness.
3. Promotes Balanced Immune Response
Studies show that CRL1505 promotes regulatory cytokines such as IL-10, which help modulate immune responses and maintain immune equilibrium.
4. Used in National Public Health Programs
CRL1505 was selected for Argentina's national public health initiative and applied in school-aged children’s nutritional programs, demonstrating both strong safety and clinical effectiveness.


About Lactobacillus rhamnosus GG (LGG)

Discovered in 1985 by the University of Helsinki in Finland, LGG is one of the most widely researched probiotic strains worldwide. Known for its high acid and bile resistance and strong colonization in the gut, LGG is a gold-standard strain for digestive and immune support.
1. Maintains Digestive Health and Microbial Balance
LGG promotes the growth of beneficial gut bacteria while inhibiting harmful strains. It supports a healthy intestinal flora, particularly in situations affected by stress, poor diet, or antibiotic use.
2. Soothes Occasional Digestive Discomfort
Research shows LGG helps relieve occasional gastrointestinal upset—such as loose stools or diarrhea—caused by travel, stress, or dietary changes. It’s also a reliable probiotic during and after antibiotic use.
3. Supports Immune Defense
LGG helps activate gut-associated lymphoid tissue (GALT) and supports the production of protective immunoglobulins like IgA, reinforcing the body’s natural defense system.
4. Extensively Studied and Safe
Lactobacillus rhamnosus GG (LGG) is one of the most widely studied and clinically supported probiotic strains, with a strong safety profile and suitability for individuals of all ages.


Scientifically Proven, Safe for Daily Use

CRL1505 and LGG are among the few probiotic strains with clinical evidence supporting both immune and respiratory health. With proven safety and effectiveness, they are ideal for daily immune and digestive support for all age groups.


References

1. Bottari, B., et al. (2021). Probiotics and Covid-19. International Journal of Food Science and Nutrution, 72(3), 293–299.
2. Salva, S., et al. (2010). Immunomodulatory activity of Lactobacillus rhamnosus strains isolated from goat milk: impact on intestinal and respiratory infections. International Journal of Food Microbiology, 141(1-2), 82–89.
3. Villena, J., et al. (2012). Orally administered Lactobacillus rhamnosus modulates the respiratory immune response triggered by the viral pathogen-associated molecular pattern poly(I:C). BMC Immunology, 13, 53
4. Villena, J. et. Al. (2011). Probiotics for Everyone! The Novel Immunobiotic Lactobacillus rhamnosus CRL1505 and the Beginning of Social Probiotic Programs in Argentina. International Journal of Biotechnology for Wellness Industries. 1, 189-198.
5. Segers, M. E., & Lebeer, S. (2014). Towards a better understanding of Lactobacillus rhamnosus GG–host interactions. Microbial Cell Factories, 13, S7.
6. Szajewska, H., et al. (2001). Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. Journal of Pediatrics, 138, 361–365.
7. Kaila, M., et al. (1992). Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatrics, 90(4), 433–438.
8. Vanderhoof, J. A. (2008). Probiotics in Allergy Management. Journal of Pediatric Gastroenterology and Nutrition, 47, S38–S40.
Back to blog